A Procedure for Creating a Frailty Index Based on Deficit Accumulation in Aging Mice
نویسندگان
چکیده
منابع مشابه
A Frailty Index Based On Deficit Accumulation Quantifies Mortality Risk in Humans and in Mice
Although many common diseases occur mostly in old age, the impact of ageing itself on disease risk and expression often goes unevaluated. To consider the impact of ageing requires some useful means of measuring variability in health in animals of the same age. In humans, this variability has been quantified by counting age-related health deficits in a frailty index. Here we show the results of ...
متن کاملA standard procedure for creating a frailty index
BACKGROUND Frailty can be measured in relation to the accumulation of deficits using a frailty index. A frailty index can be developed from most ageing databases. Our objective is to systematically describe a standard procedure for constructing a frailty index. METHODS This is a secondary analysis of the Yale Precipitating Events Project cohort study, based in New Haven CT. Non-disabled peopl...
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We previously quantified frailty in aged mice with frailty index (FI) that used specialized equipment to measure health parameters. Here we developed a simplified, noninvasive method to quantify frailty through clinical assessment of C57BL/6J mice (5-28 months) and compared the relationship between FI scores and age in mice and humans. FIs calculated with the original performance-based eight-it...
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passivity in waiting for godot and endgame: a psychoanalytic reading
this study intends to investigate samuel beckett’s waiting for godot and endgame under the lacanian psychoanalysis. it begins by explaining the most important concepts of lacanian psychoanalysis. the beckettian characters are studied regarding their state of unconscious, and not the state of consciousness as is common in most beckett studies. according to lacan, language plays the sole role in ...
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ژورنال
عنوان ژورنال: The Journals of Gerontology: Series A
سال: 2011
ISSN: 1758-535X,1079-5006
DOI: 10.1093/gerona/glr193